Raw Material Introduction｜Helichrysum

▎Essential Oil Introduction

Helichrysum is ideally sourced from Pécs, Hungary. Pécs, located in the southwestern part of Hungary, is one of the country’s oldest cities. Situated between the Danube and Drava rivers, it enjoys a pleasant climate and beautiful scenery, characterized by a continental temperate broadleaf forest climate, making it an ideal environment for growing Helichrysum.

In the perfume industry, Helichrysum is known as the "Immortelle" due to its enduring properties—its shape and color remain unchanged even after drying, earning it the nickname "Everlasting Flower." According to legend, the flower was used to quell the anger of the Greek goddess of vengeance, Machaon.

▎Component Analysis

｜Main component: Sesquiterpene ketones and esters

The primary components include italidiones and neryl acetate. Additionally, other compounds present are α-pinene, γ-curcumene, and β-selinene.

The β-diketones in Helichrysum, such as italidiones, include:

• 4,6,9-Trimethyl-8-decen-3,5-dione (Italidione I)
• 2,4,6,9-Tetramethyl-8-decen-3,5-dione (Italidione II)

｜Component 1: Italidiones

｜Component 2: Neryl acetate

｜Raw Material Certifications

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▎References

1. The antiaging properties of Helichrysum italicum (Roth) G.Don essential oil: collagenase and elastase inhibition activities.
2. ClaudiaJuliano, et al. Antimicrobial activity and chemical composition of essential oil from Helichrysum microphyllum Cambess.subsp. tyrrhenicum Bacch., Brullo & Giusso collected in South-West Sardinia. Saudi Journal of Biological Sciences.Volume 26, Issue 5, July 2019 , Pages 897-905
3. Ascrizzi, Roberta & Flamini, Guido & Fraternale, Daniele. (2017)..The antiaging properties of Helichrysum italicum (Roth) G.Don essential oil: collagenase and elastase inhibition activities.
4. Maksimovic S.et al. Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activities of prepared extracts.Phytochemistry 138 (2017) 9-28.
5. Jane Buckle, PhD, RN. Clinical Aromatherapy: Essential Oils in Healthcare (Third Edition. United Kingdom: Churchill Livingstone Elsevier, 2015)
6. Viegas, et al. Helichrysum italicum: From traditional use to scientific data.J. Ethnopharmacol. 2014, 151, 54–65.
7. Varney E, Buckle J. Effect of inhaled essential oils on mental exhaustion and moderate burnout: a small pilot study. J Altern Complement Med. 2013; 19(1): 69–71.
8. E. Guinoiseau, et al. Biological properties and resistance reversal effect of Helichrysum italicum (Roth) G. Don, 2013, Microbial pathogens and strategies for combating them : science, technology and education A. Méndez-Vilas, Ed. 2, 1073-1080.
9. C. Foti, S. Guida, et al. Allergic contact dermatitis caused by Helichrysum italicum contained in an emollient cream. Contact Dermatitis, 69 (2013), pp. 62-63
10. M. Galbany-Casals, et al. Genetic variation in Mediterranean Helichrysum italicum (Asteraceae; Gnaphalieae): do disjunct populations of subsp. microphyllum have a common origin? Plant Biol., 13 (2011), pp. 678-687.
11. Morone-Fortunato I, Montemurro C. et al.2010. Essential oils, genetic relationships and in vitro establishment of Helichrysum italicum (Roth) G. Don ssp. italicum from wild Mediterranean germplasm. Ind Crops Prod. 32:639–649 .
12. V. Lorenzi, et al. Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species. Antimucrobial Agents Chemother., 53 (2009), pp. 2209-2211
13. A. Bianchini, F. Santoni, et al. Partitioning the relative contributions of inorganic plant composition and soil characteristics to the quality of Helichrysum italicum subsp. italicum (Roth) G. Don fil. essential oil. Chem. Biodivers., 6 (2009), pp. 1014-1033
14. A.C. Lourens, A.M. Viljoen, F.R. van Heerden. South African Helichrysum species: a review of the traditional uses, biological activity and phytochemistry.J. Ethnopharmacol., 119 (2008), pp. 630-652
15. J. Mastelic, O. Politeo, et al.Composition and antimicrobial activity of Helichrysum italicum essential oil and its terpene and terpenoid fractions. Chem. Nat. Compds., 41 (2005), pp. 35-40
16. A. Sala, M.C. Recio, et al. A new dual inhibitor of arachidonate metabolism isolated from Helichrysum italicum. Eur. J. Pharmacol., 460 (2003), pp. 219-226
17. A. Sala, MC Recio, RM Giner, S. Manez, JL Rios. New acetophenone glucosides isolated from extracts of Helichrysum italicum with anti-inflammatory activity. J. Nat. Prod., 64 (2001), pp. 1360- 1362
18. Sala, A., 2001. Principios antiinflamatorios y antioxidantes de Helichrysum italicum (Roth) G. Don. PhD Thesis, University of Valencia.
19. Bianchini A, Santoni F, Paolini J, Bernardini AF, Mouillot D, Costa J. Partitioning the Relative Contributions of Inorganic Plant Composition and Soil Characteristics to the Quality of Helichrysum italicum subsp. italicum (Roth) G. Don fil. Essential Oil . Chemistry and Biodiversity. 2009; 6: 1014-1033.
20. Nostro A, Bisignano J, Cannatelli MA, Crisafi G, Germano MP, Alonzo V. Effects of Helichrysum italicum extract on growth enzymatic activity of Staphylococcus aureus. International Journal of Antimicrobial Agents. 2001 ;17: 517-520.
21. Nostro A, Cannatelli MA, Musolino AD, Procopio F, Alonzo V. Helichrysum italicum extract interferes with the productions of enterotoxins by Staphylococcus aureus. Letters in Applied Microbiology. 2002; 35: 181-184.
22. Nostro A, Cannatelli MA, Crisafi G, Musolino AD, Procopio F, Alonzo V. Modifications of hydrophobicity, in vitro adherence and cellular aggregation of Streptococcus mutans by Helichrysum italicum extract. Letters in Applied Microbiology.2004; 38: 423-427 .
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25. Lorenzi V, Muselli A, Bernardini AF, Berti L, Pages JM, Amaral L, Bolla JM. Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species. Antimicrobial agents and chemotherapy. 2009; 53: 2209-2211 .
26. Bauer J, Koeberle A, Dehma F, Pollastro F, Appendino G ,Northoff H, Rossi A, Sautebin L, Werz O. Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. Biochemical Pharmacology. 2011; 81: 259-268.
27. Nostro A, Cannatelli MA, Marino A, Picerno I, Pizzimenti FC, Scoglio ME, Spataro P. Evaluation of antiherpesvirus-1 and genotoxic activity of Helichrysum italicum extract. Microbiologica. 2003; 26: 125-128.
28. Sala A, Recio MC, Schinella GR, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL. Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside. European Journal of Pharmacology. 2003; 461: 53 -61.
29. Rosa A, Pollastro F, Atzeri A, Appendino G, Melis MP, Deiana M, Incani A, Loru D, Dessì MA. Protective role of arzanol against lipid peroxidation in biological system. Chemistry and Physics of Lipids. 2011; 164: 24-32.

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